Figure 1

MIRs are highly concentrated within enhancers. (A) Fold enrichment of MIRs in-and-around all genic enhancers (red) and intergenic enhancers (green) relative to the local genomic background (gray). (B) Average difference between transposable element densities around enhancers and around genomic background. (C) Average MIR densities for genic enhancers compared to genic background in K562 (significance level computed using the paired t test). (D) Average (±standard error) densities of MIRs in the core 200 bp of genic enhancers (white bar) versus the corresponding non-enhancer sequences of the same genes (gray).