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Figure 1 | Mobile DNA

Figure 1

From: Retrotransposition in tumors and brains

Figure 1

Bulk tissue vs. single-cell detection of somatic retrotransposition. (A) Bulk tissue sampling can underestimate the number of normal tissue retrotransposition events. (B) Single-cell sampling can provide truer estimates of rates of normal somatic cell retrotransposition. The numbers of unique de novo retrotransposon events in each cell are indicated. A minor percentage of normal epithelial cells (light brown) contain new unique insertions. Occasionally, a cancer stem cell (dark brown) gives rise to a tumor (green). Every cell of the tumor will contain the de novo retrotransposon insertions present in the originating stem cell. New tumor-specific events may also subsequently occur. Red circles indicate bulk (A) or single-cell (B) sampling for downstream sequencing analyses.

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