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Figure 3 | Mobile DNA

Figure 3

From: PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans

Figure 3

Lancelet, lamprey, and human PGBD5 are orthologous. Only shared syntenic genes are shown. The schematic is not drawn to scale, introns are not shown, genomic gaps are unsequenced, and distances are indicated in kb (red). The PGBD5 orthologs are oriented for clarity; the order and orientation of the two lamprey scaffolds is arbitrary. The 5′ and 3′ ends of lamprey GALNT2 are joined in the UCSC browser based on homology to the 5′ and 3′ ends of vertebrate GALNT2. Although >500 families of transposable elements constitute approximately 30% of the lancelet genome [32], no other PGBD5 homologs or fragments are found in the lancelet v2.0 draft genome; very similar PGBD5 sequences are present in both scaffolds 83 and 84 of the v1.0 draft genome (genome.jgi-psf.org/Brafl1/Brafl1.home.html), but PGBD5 appears only once in the v2.0 draft genome (downloadable from the UCSC browser at hgdownload.cse.ucsc.edu/gbdb/braFlo2/) in a sequence context most closely resembling scaffold 84 (Additional file 1).

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