Figure 1

Experimental outline depicting a hypothetical translocation region encompassing three translocation junctions. An illustration on the left represents the hypothesis, where there is a spatial association (symbol X) between the three observed translocation junctions (red triangles) and the nearest repeated sequence (blue arrow). Similarly, an illustration on the right represents the null hypothesis, where there is no spatial association (symbol X’) between three randomly generated translocation junctions (broken triangles) and their nearest repeat (blue arrow). We compared actual translocation junctions to 1,000 randomly generated positions to identify translocation junction regions that consistently happen near repeats.