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Figure 3 | Mobile DNA

Figure 3

From: Nuclear group I introns in self-splicing and beyond

Figure 3

Group I intron mobility. Mobility at the DNA level (left) involves a dsDNA break by the homing endonuclease (HE) at the HE recognition site followed by recombination and repair. HE-dependent mobility is unidirectional and highly efficient. Mobility at the RNA level (right) involves reverse splicing into an intron insertion site in recipient RNA molecules followed by reverse transcription and genomic integration (see text for details). Exon sequences are indicated by blue cylinders (DNA) and lines (RNA), and introns by yellow cylinders (DNA) and lines (RNA). HE: homing endonuclease; HEG: homing endonuclease gene; I+: intron-containing allele; I–: intron-lacking allele; RT: reverse transcriptase; dsDNA: double stranded DNA.

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