Retrotransposition host factor | Systematic ORF name | Cellular function | Relative Ty1 cDNA level (rhfΔ/RHF) | Genomic DNA samples analyzed (n) |
---|---|---|---|---|
Afr1 | YDR085C | Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7 to mating projections; interacts with Cdc12 | 0.42 | 2 |
Atp17 | YDR377W | Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis | 0.34 | 2 |
Bud21 | YOR078W | Also known as UTP16; component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA | 0.29 | 2 |
Cdc50 | YCR094W | Endosomal protein that interacts with phospholipid flippase Drs2; interaction with Cdc50p is essential for Drs2 catalytic activity; mutations affect cell polarity and polarized growth | 0.38 | 2 |
Cth1 | YDR151C | Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11 in iron homeostasis | 0.30 | 2 |
Dbf20 | YPR111W | Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; ortholog of human NDR2 kinase | 0.45 | 3 |
Dbp7 | YKR024C | Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis | <0.01 | 2 |
Dfg10 | YIL049W | Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; mutations in human ortholog SRD5A3 confer CDG1Q (Congenital Disorders of Glycosylation type 1Q) | 0.27 | 2 |
Dgr2 | YKL121W | Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose | 0.32 | 3 |
Dhh1 | YDL160C | Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes; ortholog of the human oncogene DDX6/p54/RCK | 0.23 | 5 |
Elp2 | YGR200C | Subunit of elongator complex, which is a component of the RNA polymerase holoenzyme and required for modification of wobble uridines in tRNA; ortholog of human ELP2/STATIP1 gene | 0.21 | 2 |
Hcr1 | YLR192C | Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20 S pre-rRNA; ortholog of human EIF3J gene | 0.29 | 3 |
Hit1 | YJR055W | Unknown function, required for growth at high temperature | 0.24 | 2 |
Hmo1 | YDR174W | Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5′-3′ DNA helicase and Fpr1, a prolyl isomerase | 0.19 | 3 |
Kgd1 | YIL125W | Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; ortholog of human OGDHL gene | 0.27 | 2 |
Loc1 | YFR001W | Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; co-localizes with large subunit precursor of ribosome | 0.14 | 3 |
Los1 | YKL205W | Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after retrograde import from the cytoplasm; ortholog of human exportin-T gene, XPOT | 0.44 | 3 |
Lst7 | YGR057C | Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1 from the Golgi to the cell surface | 0.44 | 4 |
Mrt4 | YKL009W | Protein involved in mRNA turnover and large ribosome assembly, co-localizes with large subunit precursor of ribosome; ortholog of human MRTO4 gene | 0.17 | 2 |
Ncl1 | YBL024W | S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2 and human proliferation associated nucleolar protein p120 | 0.49 | 4 |
Oca4 | YCR095C | Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses | 0.43 | 2 |
Ref2 | YDR195W | RNA-binding protein involved in the cleavage step of mRNA 3′-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3′-ends of snoRNA- and mRNA-encoding genes | 0.17 | 2 |
Rkm4 | YDR257C | Ribosomal lysine methyltransferase specific for monomethylation of Rpl42a and Rpl42b (lysine 55); nuclear SET-domain containing protein | 0.41 | 2 |
Rpl7a | YGL076C | Protein component of the large (60 S) ribosomal subunit, nearly identical to Rpl7b; ortholog of human L7 ribosomal protein gene | 0.15 | 4 |
Rpl19a | YBR084C-A | Protein component of the large (60 S) ribosomal subunit, nearly identical to Rpl19b; ortholog of human L19 ribosomal protein gene | 0.24 | 2 |
Rpl27a | YGL076C | Protein component of the large (60 S) ribosomal subunit; nearly identical to Rpl27b; ortholog of human L27 ribosomal protein gene | 0.19 | 2 |
Rpl31a | YDL075W | Protein component of the large (60 S) ribosomal subunit, nearly identical to Rpl31b; ortholog of human L31 ribosomal protein gene | 0.10 | 2 |
Rpl43a | YPR043W | Protein component of the large (60 S) ribosomal subunit, identical to Rpl43b; ortholog of human ribosomal protein L37 gene | 0.15 | 3 |
Rps19b | YNL302C | Protein component of the small (40 S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19a | 0.28 | 4 |
Rps25a | YGR027C | Protein component of the small (40 S) ribosomal subunit; nearly identical to Rps25b; ortholog of human S25 ribosomal protein gene | 0.19 | 2 |
Rps30a | YLR287C-A | Protein component of the small (40 S) ribosomal subunit; nearly identical to Rps30B; ortholog of human S30 ribosomal protein | 0.20 | 2 |
Snf5 | YBR289W | Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2 and Snf6 | 0.09 | 2 |
Snf6 | YHL025W | Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2 and Snf5 | 0.27 | 2 |
Snt1 | YCR033W | Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein | 0.21 | 2 |
Spf1 | YEL031W | P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2 degradation | 0.42 | 2 |
Spt3 | YDR392W | Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15 to activate transcription of some RNA polymerase II-dependent genes; also inhibits transcription at some promoters | 0.09 | 3 |
Spt8 | YLR055C | Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters | 0.10 | 2 |
Sse1 | YPL106C | ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the HSP70 family | 0.25 | 2 |
Swi3 | YJL176C | Subunit of the SWI/SNF chromatin remodeling complex | 0.44 | 3 |
Ump1 | YBR173C | Short-lived chaperone required for correct maturation of the 20 S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly | 0.36 | 3 |
Upf1 | YMR080C | Also known as Nam7; ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance | 0.25 | 4 |
Upf3 | YGR072W | Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Upf1 and Upf2; involved in decay of mRNA containing nonsense codons and telomere maintenance; ortholog of human UPF3A and UPF3B genes | 0.29 | 4 |
YDL124W | YDL124W | NADPH-dependent alpha-keto amide reductase | 0.36 | 2 |