Figure 4From: Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kineticsRepression of Alu Mobilization is not altered by nucleotide sequence variations in L1 open reading frame (ORF)2. In HeLa ORF2 and HeLa ORF2 ER-- cells, mobilization of a previously described tagged Alu element [45] driven by three synthetic L1 ORF2s [21], each varying in their nucleotide but not amino acid sequence, was measured. Data are means and SD (error bars) of three independent measurements. Asterisks signify a significant (Student t-test, P ≤ 0.005) difference from retrotransposition levels seen in HeLa ORF2 ER-- cells.Back to article page