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Figure 4 | Mobile DNA

Figure 4

From: Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics

Figure 4

Repression of Alu Mobilization is not altered by nucleotide sequence variations in L1 open reading frame (ORF)2. In HeLa ORF2 and HeLa ORF2 ER-- cells, mobilization of a previously described tagged Alu element [45] driven by three synthetic L1 ORF2s [21], each varying in their nucleotide but not amino acid sequence, was measured. Data are means and SD (error bars) of three independent measurements. Asterisks signify a significant (Student t-test, P ≤ 0.005) difference from retrotransposition levels seen in HeLa ORF2 ER-- cells.

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