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  1. Research

    Convergence of retrotransposons in oomycetes and plants

    Retrotransposons comprise a ubiquitous and abundant class of eukaryotic transposable elements. All members of this class rely on reverse transcriptase activity to produce a DNA copy of the element from the RNA...

    Kirill Ustyantsev, Alexandr Blinov and Georgy Smyshlyaev

    Mobile DNA 2017 8:4

    Published on: 14 March 2017

  2. Research

    Non-canonical Helitrons in Fusarium oxysporum

    Helitrons are eukaryotic rolling circle transposable elements that can have a large impact on host genomes due to their copy-number and their ability to capture and copy genes and regulatory elements. They occ...

    Biju Vadakkemukadiyil Chellapan, Peter van Dam, Martijn Rep, Ben J. C. Cornelissen and Like Fokkens

    Mobile DNA 2016 7:27

    Published on: 9 December 2016

  3. Research

    The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation

    Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, ex...

    Felix Broecker, Roger Horton, Jochen Heinrich, Alexandra Franz, Michal-Ruth Schweiger, Hans Lehrach and Karin Moelling

    Mobile DNA 2016 7:25

    Published on: 7 December 2016

  4. Review

    Endogenous retroviral promoter exaptation in human cancer

    Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor suppressor genes. Aberrant...

    Artem Babaian and Dixie L. Mager

    Mobile DNA 2016 7:24

    Published on: 1 December 2016

  5. Research

    Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

    LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms follo...

    Patricia E. Carreira, Adam D. Ewing, Guibo Li, Stephanie N. Schauer, Kyle R. Upton, Allister C. Fagg, Santiago Morell, Michaela Kindlova, Patricia Gerdes, Sandra R. Richardson, Bo Li, Daniel J. Gerhardt, Jun Wang, Paul M. Brennan and Geoffrey J. Faulkner

    Mobile DNA 2016 7:21

    Published on: 11 November 2016

  6. Research

    Somatic retrotransposition is infrequent in glioblastomas

    Gliomas are the most common primary brain tumors in adults. We sought to understand the roles of endogenous transposable elements in these malignancies by identifying evidence of somatic retrotransposition in ...

    Pragathi Achanta, Jared P. Steranka, Zuojian Tang, Nemanja Rodić, Reema Sharma, Wan Rou Yang, Sisi Ma, Mark Grivainis, Cheng Ran Lisa Huang, Anna M. Schneider, Gary L. Gallia, Gregory J. Riggins, Alfredo Quinones-Hinojosa, David Fenyö, Jef D. Boeke and Kathleen H. Burns

    Mobile DNA 2016 7:22

    Published on: 11 November 2016

  7. Research

    A map of mobile DNA insertions in the NCI-60 human cancer cell panel

    The National Cancer Institute-60 (NCI-60) cell lines are among the most widely used models of human cancer. They provide a platform to integrate DNA sequence information, epigenetic data, RNA and protein expre...

    John G. Zampella, Nemanja Rodić, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby C. Cornish, Jef D. Boeke and Kathleen H. Burns

    Mobile DNA 2016 7:20

    Published on: 31 October 2016

  8. Meeting report

    International Congress on Transposable elements (ICTE 2016) in Saint Malo: mobile elements under the sun of Brittany

    The third international conference on Transposable Elements (ICTE) was held 16–19 April 2016 in Saint Malo, France. Organized by the French Transposition Community (Research group of the CNRS: “Mobile genetic ...

    Pascale Lesage, Mireille Bétermier, Antoine Bridier-Nahmias, Michael Chandler, Séverine Chambeyron, Gael Cristofari, Nicolas Gilbert, Hadi Quesneville, Chantal Vaury and Jean-Nicolas Volff

    Mobile DNA 2016 7:19

    Published on: 20 October 2016

  9. Short report

    Functional opsin retrogene in nocturnal moth

    Retrotransposed genes are different to other types of genes as they originate from a processed mRNA and are then inserted back into the genome. For a long time, the contribution of this mechanism to the origin...

    Pengjun Xu, Roberto Feuda, Bin Lu, Haijun Xiao, Robert I. Graham and Kongming Wu

    Mobile DNA 2016 7:18

    Published on: 19 October 2016

  10. Research

    Convergent evolution of tRNA gene targeting preferences in compact genomes

    In gene-dense genomes, mobile elements are confronted with highly selective pressure to amplify without causing excessive damage to the host. The targeting of tRNA genes as potentially safe integration sites h...

    Thomas Spaller, Eva Kling, Gernot Glöckner, Falk Hillmann and Thomas Winckler

    Mobile DNA 2016 7:17

    Published on: 31 August 2016

  11. Review

    Restricting retrotransposons: a review

    Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on the non-long terminal repeat ret...

    John L. Goodier

    Mobile DNA 2016 7:16

    Published on: 11 August 2016

  12. Research

    Virus-like attachment sites as structural landmarks of plants retrotransposons

    The genomic data available nowadays has enabled the study of repetitive sequences and their relationship to viruses. Among them, long terminal repeat retrotransposons (LTR-RTs) are the largest component of mos...

    Edgar Andres Ochoa Cruz, Guilherme Marcello Queiroga Cruz, Andréia Prata Vieira and Marie-Anne Van Sluys

    Mobile DNA 2016 7:14

    Published on: 28 July 2016

  13. Research

    Genomic analysis of mouse VL30 retrotransposons

    Retrotransposons are mobile elements that have a high impact on shaping the mammalian genomes. Since the availability of whole genomes, genomic analyses have provided novel insights into retrotransposon biolog...

    Georgios Markopoulos, Dimitrios Noutsopoulos, Stefania Mantziou, Demetrios Gerogiannis, Soteroula Thrasyvoulou, Georgios Vartholomatos, Evangelos Kolettas and Theodore Tzavaras

    Mobile DNA 2016 7:10

    Published on: 6 May 2016

  14. Review

    Roles for retrotransposon insertions in human disease

    Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter time scale it has been established that new TE in...

    Dustin C. Hancks and Haig H. Kazazian

    Mobile DNA 2016 7:9

    Published on: 6 May 2016

  15. Research

    The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations

    Approximately 17 % of the human genome is comprised of the Long INterspersed Element-1 (LINE-1 or L1) retrotransposon, the only currently active autonomous family of retroelements. Though L1 elements have helped ...

    Kristine J. Kines, Mark Sokolowski, Dawn L. deHaro, Claiborne M. Christian, Melody Baddoo, Madison E. Smither and Victoria P. Belancio

    Mobile DNA 2016 7:8

    Published on: 19 April 2016

  16. Methodology

    Alu SINE analyses of 3,000-year-old human skeletal remains: a pilot study

    As Short Interspersed Elements (SINEs), human-specific Alu elements can be used for population genetic studies. Very recent inserts are polymorphic within and between human populations. In a sample of 30 elements...

    Maximilian Kothe, Verena Seidenberg, Susanne Hummel and Oliver Piskurek

    Mobile DNA 2016 7:7

    Published on: 18 April 2016

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